JunB antibody (C-Term)

Catalog No. ABIN2780414

This anti-JunB antibody is a Rabbit Polyclonal antibody detecting JunB in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Sheep, Horse, Guinea Pig, Zebrafish (Danio rerio), Goat, Rabbit and Saccharomyces cerevisiae.

Quick Overview for JunB antibody (C-Term) (ABIN2780414)

Target: JunB (JUNB) (Jun B Proto-Oncogene (JUNB))

Reactivity: Human, Mouse, Rat, Cow, Dog, Sheep, Horse, Guinea Pig, Zebrafish (Danio rerio), Goat, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JunB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-JunB Antibody

Binding Specificity: C-Term

Sequence: VERKRLRNRL AATKCRKRKL ERIARLEDKV KTLKAENAGL SSTAGLLREQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 100%, Sheep: 100%, Yeast: 91%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against JUNB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human JUNB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 347 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for JunB

Target: JunB (JUNB) (Jun B Proto-Oncogene (JUNB))

Alternative Name: JUNB

Background: The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
Alias Symbols: AP-1
Protein Interaction Partner: BATF, FOS, RFWD2, C19orf68, USP24, TCERG1, ZNF595, PKIA, MAP2, APLP2, FOSL1, DDIT3, ATF3, BATF2, BATF3, TCL1A, FOSL2, NPM1, NEU1, SMAD4, HOXA7, BDNF, ATF4, MAPK6, UBC, TDG, SET, SAT1, MAPK9, BRCA1, SUMO2, Cebpb, EP300, SMURF1, YY1, CREBBP, SMARCA4, JDP2,
Protein Size: 347

Molecular Weight: 36 kDa

Gene ID: 3726

NCBI Accession: NM_002229, NP_002220

UniProt: P17275