GSC2 antibody (C-Term)

Catalog No. ABIN2780669

This Rabbit Polyclonal antibody specifically detects GSC2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for GSC2 antibody (C-Term) (ABIN2780669)

Target: GSC2 (Goosecoid Homeobox 2 (GSC2))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GSC2 Antibody

Binding Specificity: C-Term

Purpose: GSCL Antibody - C-terminal region

Sequence: LEALFVQNQY PDVSTRERLA GRIRLREERV EVWFKNRRAK WRHQKRASAS

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against GSCL. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GSCL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101870

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GSC2

Target: GSC2 (Goosecoid Homeobox 2 (GSC2))

Alternative Name: GSCL

Background:

Background Information: Goosecoidlike (GSCL) resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology.Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development.

Gene Name: Goosecoid homeobox 2

Alternative Symbols: GSCL

Protein Name: Homeobox protein goosecoid-2

Molecular Weight: 22kDa

Gene ID: 2928

NCBI Accession: NP_005306

UniProt: O15499