FOXO4 antibody (C-Term)

Catalog No. ABIN2780728

This anti-FOXO4 antibody is a Rabbit Polyclonal antibody detecting FOXO4 in WB. Suitable for Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig and Rabbit.

Quick Overview for FOXO4 antibody (C-Term) (ABIN2780728)

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOXO4 Antibody

Binding Specificity: C-Term

Sequence: PPVMAGAPIP KVLGTPVLAS PTEDSSHDRM PQDLDLDMYM ENLECDMDNI

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Foxo4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 505 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FOXO4

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Alternative Name: Foxo4

Background: Foxo4 is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. It down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. It represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin.
Alias Symbols: Afxh, MGC117660, Mllt7, afx
Protein Size: 505

Molecular Weight: 54 kDa

Gene ID: 54601

NCBI Accession: NM_001005872, NP_001005872

UniProt: Q99MK2

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation