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GLS2 antibody (Middle Region)

GLS2 Reactivity: Human, Mouse, Rat, Pig, Dog, Zebrafish (Danio rerio), Horse, Rabbit, Cow, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2781319
  • Target See all GLS2 Antibodies
    GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))
    Binding Specificity
    • 15
    • 8
    • 8
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Pig, Dog, Zebrafish (Danio rerio), Horse, Rabbit, Cow, Guinea Pig
    Host
    • 40
    • 4
    Rabbit
    Clonality
    • 40
    • 4
    Polyclonal
    Conjugate
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GLS2 antibody is un-conjugated
    Application
    • 23
    • 22
    • 15
    • 13
    • 13
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    FVGKEPSGLR YNKLSLNEEG IPHNPMVNAG AIVVSSLIKM DCNKAEKFDF
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%
    Characteristics
    This is a rabbit polyclonal antibody against GLS2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human GLS2
    Top Product
    Discover our top product GLS2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 327 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

    Toriumi, Mouri, Narusawa, Aoyama, Ikawa, Lu, Nagai, Mamiya, Kim, Nabeshima: "Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 6, pp. 1387-96, (2012) (PubMed).

  • Target
    GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))
    Alternative Name
    GLS2 (GLS2 Products)
    Synonyms
    si:ch211-216k22.10 antibody, GA antibody, GLS antibody, LGA antibody, hLGA antibody, A330074B06Rik antibody, AI195532 antibody, Lga antibody, Ga antibody, glutaminase 2 antibody, glutaminase 2a (liver, mitochondrial) antibody, glutaminase 2 (liver, mitochondrial) antibody, glsA2 antibody, LOAG_03311 antibody, gls2a antibody, GLS2 antibody, Gls2 antibody
    Background
    GLS2 is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well.
    Alias Symbols: GA, GLS, LGA, MGC71567, hLGA
    Protein Interaction Partner: SNTA1, GRHPR, TAX1BP3, PAG1, DLG2, INADL, DLG4, RGS3, DLG1, DLG3, CASK,
    Protein Size: 327
    Molecular Weight
    36 kDa
    Gene ID
    27165
    NCBI Accession
    NM_013267
    UniProt
    Q9UI32
    Pathways
    Dicarboxylic Acid Transport, Warburg Effect
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