CPB2 antibody (Middle Region)

Catalog No. ABIN405576

The Rabbit Polyclonal anti-CPB2 antibody (ABIN405576) specifically detects CPB2 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig, Horse and Rabbit samples.

Quick Overview for CPB2 antibody (Middle Region) (ABIN405576)

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CPB2 Antibody

Binding Specificity: Middle Region

Purpose: CPB2 Antibody - middle region

Sequence: RSKSKDHEEL SLVASEAVRA IEKTSKNTRY THGHGSETLY LAPGGGDDWI

Predicted Reactivity: Dog: 86%, Guinea Pig: 83%, Horse: 85%, Human: 100%, Mouse: 92%, Rabbit: 83%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against CPB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CPB2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43570-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CPB2

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Alternative Name: CPB2

Background:

Background Information: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms.

Gene Name: Carboxypeptidase B2 (plasma)

Alternative Symbols: CPU, PCPB, TAFI

Protein Name: Carboxypeptidase B2

Molecular Weight: 36kDa

Gene ID: 1361

NCBI Accession: NP_001863

UniProt: Q96IY4

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis