ABCA7 antibody (Middle Region)

Catalog No. ABIN2781526

Cited in 1 publication. The Rabbit Polyclonal anti-ABCA7 antibody (ABIN2781526) specifically detects ABCA7 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog and Guinea Pig samples.

Quick Overview for ABCA7 antibody (Middle Region) (ABIN2781526)

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCA7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ABCA7 Antibody

Binding Specificity: Middle Region

Sequence: DTQTRHLSGG MQRKLSVAIA FVGGSRVVIM DEPTAGVDPA SRRGIWELLL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Abca7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2159 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ABCA7 antibody (ABIN2781526)

Bamji-Mirza, Li, Najem, Liu, Walker, Lue, Stupak, Chan, Li, Ghani, Yang, Rogaeva, Zhang: "Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models." in: Journal of Alzheimer's disease : JAD, Vol. 53, Issue 3, pp. 875-92, (2016) (PubMed).

Target Details for ABCA7

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Alternative Name: Abca7

Background: Abca7 plays a role in phagocytosis by macrophages of apoptotic cells.Abca7 binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. Abca7 may also mediate cholesterol efflux. Abca7 may regulate cellular ceramide homeostasis during keratinocytes differentiation.
Alias Symbols: ABCX, Abc51
Protein Size: 2159

Molecular Weight: 237 kDa

Gene ID: 27403

NCBI Accession: NM_013850, NP_038878

UniProt: Q91V24