ABCA7 antibody (N-Term)

Catalog No. ABIN6991700

Product Details anti-ABCA7 Antibody

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Binding Specificity: AA 130-180, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCA7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Specificity: ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.

Purification: ABCA7 Antibody is affinity chromatography purified via peptide column.

Immunogen: ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7. The immunogen is located within amino acids 130 - 180 of ABCA7.

Isotype: IgG

Application Details

Application Notes: ABCA7 antibody can be used for detection of ABCA7 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL and immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ABCA7 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ABCA7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ABCA7

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Alternative Name: ABCA7 (ABCA7 Products)

Synonyms: ABCX antibody, Abc51 antibody, ABCA-SSN antibody, ABCA7 antibody, ATP-binding cassette, sub-family A (ABC1), member 7 antibody, ATP binding cassette subfamily A member 7 antibody, ATP-binding cassette sub-family A member 7 antibody, Abca7 antibody, ABCA7 antibody, LOC100088822 antibody

Background: ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

Molecular Weight: Predicted: 236 kDa

Observed: 240 kDa

Gene ID: 10347

NCBI Accession: NP_061985

UniProt: Q8IZY2