Growth Hormone Receptor antibody (C-Term)

Catalog No. ABIN2781773

The Rabbit Polyclonal anti-Growth Hormone Receptor antibody is suitable to detect Growth Hormone Receptor in samples from Human, Horse, Dog and Pig. It has been validated for WB.

Quick Overview for Growth Hormone Receptor antibody (C-Term) (ABIN2781773)

Target: Growth Hormone Receptor (GHR)

Reactivity: Human, Horse, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Growth Hormone Receptor Antibody

Binding Specificity: C-Term

Purpose: GHR Antibody - C-terminal region

Sequence: YSLKVDKEYE VRVRSKQRNS GNYGEFSEVL YVTLPQMSQF TCEEDFYFPW

Predicted Reactivity: Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human GHR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44231-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: GHR

Background:

Background Information: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein.

Gene Name: growth hormone receptor

Alternative Symbols: GHBP, GHIP

Protein Name: Growth hormone receptor

Molecular Weight: 32kDa

Gene ID: 2690

NCBI Accession: NP_001229391

UniProt: P10912

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus