Calsyntenin 1 antibody (N-Term)

Catalog No. ABIN2781932

The Rabbit Polyclonal anti-Calsyntenin 1 antibody is suitable to detect Calsyntenin 1 in samples from Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Dog. It has been validated for WB.

Quick Overview for Calsyntenin 1 antibody (N-Term) (ABIN2781932)

Target: Calsyntenin 1 (CLSTN1)

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calsyntenin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Calsyntenin 1 Antibody

Binding Specificity: N-Term

Purpose: CLSTN1 Antibody - N-terminal region

Sequence: KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI

Predicted Reactivity: Cow: 82%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against CLSTN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLSTN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44580-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Calsyntenin 1

Target: Calsyntenin 1 (CLSTN1)

Alternative Name: CLSTN1

Background:

Background Information: CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.

Gene Name: Calsyntenin 1

Alternative Symbols: CST-1, CSTN1, CDHR12, PIK3CD, ALC-ALPHA, XB31alpha, alcalpha1, alcalpha2

Protein Name: Calsyntenin-1

Molecular Weight: 110kDa

Gene ID: 22883

NCBI Accession: NP_001009566

UniProt: O94985