ITM2C antibody (Middle Region)

Catalog No. ABIN2781948

The Rabbit Polyclonal anti-ITM2C antibody (ABIN2781948) specifically detects ITM2C in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for ITM2C antibody (Middle Region) (ABIN2781948)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ITM2C Antibody

Binding Specificity: Middle Region

Purpose: ITM2C Antibody - middle region

Sequence: EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against ITM2C. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44631-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: ITM2C

Background:

Background Information: ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.

Gene Name: Integral membrane protein 2C

Alternative Symbols: E25, BRI3, E25C, ITM3, BRICD2C

Protein Name: Integral membrane protein 2C

Molecular Weight: 30kDa

Gene ID: 81618

NCBI Accession: NP_112188

UniProt: Q9NQX7