P-Cadherin antibody (N-Term)

Catalog No. ABIN2782138

The Rabbit Polyclonal anti-P-Cadherin antibody (ABIN2782138) specifically detects P-Cadherin in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit samples.

Quick Overview for P-Cadherin antibody (N-Term) (ABIN2782138)

Target: P-Cadherin (CDH3)

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-P-Cadherin Antibody

Binding Specificity: N-Term

Purpose: CDH3 Antibody - N-terminal region

Sequence: AVSENGASVE DPMNISIIVT DQNDHKPKFT QDTFRGSVLE GVLPGTSVMQ

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CDH3. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CDH3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45170-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: CDH3

Background:

Background Information: CDH3 is a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Its gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in its gene have been associated with congential hypotrichosis with juvenile macular dystrophy.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

Gene Name: Cadherin 3, type 1, P-cadherin (placental)

Alternative Symbols: CDHP, HJMD, PCAD

Protein Name: Cadherin-3

Molecular Weight: 91kDa

Gene ID: 1001

NCBI Accession: NP_001784

UniProt: P22223