Fc epsilon RI/FCER1A antibody (N-Term)

Catalog No. ABIN2782150

The Rabbit Polyclonal anti-Fc epsilon RI/FCER1A antibody (ABIN2782150) specifically detects Fc epsilon RI/FCER1A in WB. The antibody is reactive with Human samples.

Quick Overview for Fc epsilon RI/FCER1A antibody (N-Term) (ABIN2782150)

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fc epsilon RI/FCER1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Fc epsilon RI/FCER1A Antibody

Binding Specificity: N-Term

Purpose: FCER1A Antibody - N-terminal region

Sequence: NPPWNRIFKG ENVTLTCNGN NFFEVSSTKW FHNGSLSEET NSSLNIVNAK

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against FCER1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FCER1A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45203-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Fc epsilon RI/FCER1A

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Alternative Name: FCER1A

Background:

Targeted Subunit: alpha

Background Information: The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139), only the alpha subunit is glycosylated.

Gene Name: Fc fragment of IgE, high affinity I, receptor for, alpha polypeptide

Alternative Symbols: FCE1A, FcERI

Protein Name: High affinity immunoglobulin epsilon receptor subunit alpha

Molecular Weight: 27kDa

Gene ID: 2205

NCBI Accession: NP_001992

UniProt: P12319

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process