HMOX1 antibody (N-Term)

Catalog No. ABIN2782158

This Rabbit Polyclonal antibody specifically detects HMOX1 in WB. It exhibits reactivity toward Human, Rat, Mouse, Pig, Cow, Dog, Guinea Pig, Rabbit and Goat. It has been mentioned in 2+ publications

Quick Overview for HMOX1 antibody (N-Term) (ABIN2782158)

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Reactivity: Human, Rat, Mouse, Pig, Cow, Dog, Guinea Pig, Rabbit, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMOX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HMOX1 Antibody

Binding Specificity: N-Term

Purpose: HMOX1 Antibody - N-terminal region

Sequence: ERPQPDSMPQ DLSEALKEAT KEVHTQAENA EFMRNFQKGQ VTRDGFKLVM

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HMOX1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HMOX1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45222-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-HMOX1 antibody (ABIN2782158)

Kawahara, Gasperini, Myers, Widrick, Eran, Serafini, Alexander, Pletcher, Morris, Kunkel: "Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling." in: Human molecular genetics, Vol. 23, Issue 7, pp. 1869-78, (2014) (PubMed).

Hausmann, Paul, Kellermeier, Frey, Schölmerich, Falk, Menzel, Fried, Herfarth, Rogler: "(GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course." in: Clinical and experimental immunology, Vol. 153, Issue 1, pp. 81-5, (2008) (PubMed).

Target Details for HMOX1

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Alternative Name: HMOX1

Background:

Background Information: HMOX1 belongs to the heme oxygenase family. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2.

Gene Name: Heme oxygenase (decycling) 1

Alternative Symbols: HO-1, HSP32, HMOX1D, bK286B10

Protein Name: Heme oxygenase 1

Molecular Weight: 33kDa

Gene ID: 3162

NCBI Accession: NP_002124

UniProt: P09601

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome