Non-Syndromic Hearing Impairment Protein 5 (GSDME) (C-Term) antibody

Catalog No. ABIN2782489

The Rabbit Polyclonal anti-Non-Syndromic Hearing Impairment Protein 5 antibody is suitable to detect Non-Syndromic Hearing Impairment Protein 5 in samples from Human, Rat, Dog, Guinea Pig and Cow. It has been validated for WB and IHC.

Quick Overview for Non-Syndromic Hearing Impairment Protein 5 (GSDME) (C-Term) antibody (ABIN2782489)

Target: Non-Syndromic Hearing Impairment Protein 5 (GSDME)

Reactivity: Human, Rat, Dog, Guinea Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details

Binding Specificity: C-Term

Purpose: GSDME Antibody - C-terminal region

Sequence: AALLGTCCKL QIIPTLCHLL RALSDDGVSD LEDPTLTPLK DTERFGIVQR

Predicted Reactivity: Cow: 85%, Dog: 77%, Guinea Pig: 83%, Human: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against DFNA5. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DFNA5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46106-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Non-Syndromic Hearing Impairment Protein 5 (GSDME)

Alternative Name: GSDME

Background:

Background Information: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.

Gene Name: gasdermin E

Alternative Symbols: DFNA5, ICERE-1

Protein Name: gasdermin-E

Molecular Weight: 47kDa

Gene ID: 1687

UniProt: A4FVA8