FAP antibody (C-Term)

Catalog No. ABIN2782638

This Rabbit Polyclonal antibody specifically detects FAP in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig and Rabbit.

Quick Overview for FAP antibody (C-Term) (ABIN2782638)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FAP Antibody

Binding Specificity: C-Term

Purpose: FAP Antibody - C-terminal region

Sequence: SWEYYASVYT ERFMGLPTKD DNLEHYKNST VMARAEYFRN VDYLLIHGTA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against FAP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human FAP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46455-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Alternative Name: FAP

Background:

Background Information: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

Gene Name: fibroblast activation protein, alpha

Alternative Symbols: FAPA, SIMP, DPPIV, FAPalpha

Protein Name: Seprase

Molecular Weight: 26kDa

Gene ID: 2191

NCBI Accession: NP_004451

UniProt: Q12884

Pathways: Tube Formation