IL11RA antibody (Interleukin 11 Receptor, alpha) (Middle Region)

Details for Product anti-IL11RA Antibody No. ABIN2782642, Supplier: Log in to see
Antigen
  • CRSDA
  • fi26e06
  • il-11ra
  • wu:fi26e06
  • AI314697
  • GP130
  • Il-11ra
  • Il11ra
  • Il11ra2
  • NR1
  • interleukin 11 receptor subunit alpha
  • interleukin 11 receptor, alpha
  • interleukin 11 receptor subunit alpha 1
  • interleukin 11 receptor, alpha chain 1
  • IL11RA
  • il11ra
  • Il11ra1
  • Il11ra
Alternatives
anti-Human IL11RA antibody for Western Blotting
Epitope
Middle Region
5
5
5
4
3
3
3
3
2
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
48
30
19
3
3
3
3
2
1
1
1
Host
Rabbit
56
7
Clonality
Polyclonal
Conjugate
This IL11RA antibody is un-conjugated
4
3
Application
Western Blotting (WB)
52
40
18
5
5
4
3
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human IL11RA
Blocking Peptide Blocking peptide for this product available: ABIN978470
Sequence FLLKFRLQYR PAQHPAWSTV EPAGLEEVIT DAVAGLPHAV RVSARDFLDA
Predicted Reactivity Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against IL11RA. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name IL11RA (IL11RA Antibody Abstract)
Background Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. IL11RA is the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain.Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
Alias Symbols: MGC2146, CRSDA
Protein Interaction Partner: IL11,
Protein Size: 422
Molecular Weight 43 kDa
Gene ID 3590
NCBI Accession NM_004512, NP_004503
UniProt Q14626
Research Area Cancer, Hematopoietic Progenitors, Innate Immunity, Cytokines
Pathways JAK-STAT Signaling, Growth Factor Binding
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 422 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Interleukin 11 Receptor, alpha (IL11RA) (Middle Region) antibody (ABIN2782642) anti-Interleukin 11 Receptor, alpha (IL11RA) (Middle Region) antibody
Background publications Nakayama, Yoshizaki, Izumida, Suehiro, Miura, Uemura, Yakata, Shichijo, Yamashita, Sekin: "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells." in: International journal of oncology, Vol. 30, Issue 4, pp. 825-33, 2007 (PubMed).

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