WNT6 antibody (Middle Region)

Catalog No. ABIN2782719

The Rabbit Polyclonal anti-WNT6 antibody is suitable to detect WNT6 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit and Guinea Pig. It has been validated for WB.

Quick Overview for WNT6 antibody (Middle Region) (ABIN2782719)

Target: WNT6 (Wingless-Type MMTV Integration Site Family, Member 6 (WNT6))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNT6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WNT6 Antibody

Binding Specificity: Middle Region

Sequence: ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against WNT6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human WNT6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 365 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for WNT6

Target: WNT6 (Wingless-Type MMTV Integration Site Family, Member 6 (WNT6))

Alternative Name: WNT6

Background: The WNT family consists of several secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT6 is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The WNT6 protein overexpression may play key roles in carcinogenesis. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97 % identical to the mouse Wnt6 protein at the amino acid level.
Alias Symbols: -
Protein Interaction Partner: PORCN,
Protein Size: 365

Molecular Weight: 37 kDa

Gene ID: 7475

NCBI Accession: NM_006522, NP_006513

UniProt: Q9Y6F9

Pathways: WNT Signaling, Tube Formation