AFG3L2 antibody (Middle Region)

Catalog No. ABIN2782736

The Rabbit Polyclonal anti-AFG3L2 antibody is suitable to detect AFG3L2 in samples from Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse, Rabbit, Goat and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for AFG3L2 antibody (Middle Region) (ABIN2782736)

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse, Rabbit, Goat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFG3L2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AFG3L2 Antibody

Binding Specificity: Middle Region

Purpose: AFG3L2 Antibody - middle region

Sequence: VNFLKNPKQY QDLGAKIPKG AILTGPPGTG KTLLAKATAG EANVPFITVS

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 79%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against AFG3L2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AFG3L2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46780-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for AFG3L2

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Alternative Name: AFG3L2

Background:

Background Information: AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.

Gene Name: AFG3 ATPase family gene 3-like 2 (S. cerevisiae)

Alternative Symbols: OPA12, SCA28, SPAX5

Protein Name: AFG3-like protein 2

Molecular Weight: 88kDa

Gene ID: 10939

NCBI Accession: NP_006787

UniProt: Q9Y4W6

Pathways: Skeletal Muscle Fiber Development