BMP10 antibody (N-Term)

Catalog No. ABIN2782813

The Rabbit Polyclonal anti-BMP10 antibody is suitable to detect BMP10 in samples from Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for BMP10 antibody (N-Term) (ABIN2782813)

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BMP10 Antibody

Binding Specificity: N-Term

Purpose: Bmp10 Antibody - N-terminal region

Sequence: KFATDRTSMP SANIIRSFKN EDLFSQPVSF NGIRKYPLLF NVSIPHHEEV

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Bmp10. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Rat

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47031-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BMP10

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Alternative Name: Bmp10

Background:

Background Information: Bmp10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Bmp10 acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Bmp10 inhibits endothelial cell migration and growth.

Gene Name: Bone morphogenetic protein 10

Alternative Symbols: Bmp10

Protein Name: Bone morphogenetic protein 10

Molecular Weight: 48kDa

Gene ID: 500245

NCBI Accession: NP_001026994

UniProt: Q4AEG6

Pathways: Hormone Activity, Regulation of Muscle Cell Differentiation