BMP10 antibody (C-Term)

Catalog No. ABIN2782814

Product Details anti-BMP10 Antibody

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP10 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GYEAYECRGV CNYPLAEHLT PTKHAIIQAL VHLKNSQKAS KACCVPTKLE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against BMP10. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human BMP10

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BMP10

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Alternative Name: BMP10 (BMP10 Products)

Synonyms: BMP10 antibody, si:dkey-13n15.5 antibody, Bmp10 antibody, BMP9 antibody, BMP-10 antibody, bone morphogenetic protein 10 antibody, BMP10 antibody, bmp10 antibody, LOC662386 antibody, Bmp10 antibody

Background: BMP10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Alias Symbols: -
Protein Interaction Partner: BMPR2, ACVR2B, ACVR2A, SERINC3,
Protein Size: 424

Molecular Weight: 46 kDa

Gene ID: 27302

NCBI Accession: NM_014482, NP_055297

UniProt: O95393

Pathways: Hormone Activity, Regulation of Muscle Cell Differentiation