HSD17B12 antibody (C-Term)

Catalog No. ABIN2782872

Product Details anti-HSD17B12 Antibody

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B12 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SAETFVKSAI KTVGLQTRTT GYVIHSLMGS INSIMPRWMY FKIIMGFSKS

Predicted Reactivity: Cow: 79%, Dog: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 79%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Hsd17b12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Hsd17b12

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 312 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSD17B12

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Alternative Name: Hsd17b12 (HSD17B12 Products)

Synonyms: KAR antibody, SDR12C1 antibody, 2610510O05Rik antibody, AI172963 antibody, KIK-I antibody, Kik1 antibody, HSD17B12 antibody, kar antibody, sdr12c1 antibody, 17-beta-HSD 12-A antibody, fi06g11 antibody, wu:fi06g11 antibody, zf3.1 antibody, zfHSD17B12A antibody, zgc:55589 antibody, zgc:77599 antibody, hydroxysteroid 17-beta dehydrogenase 12 antibody, hydroxysteroid (17-beta) dehydrogenase 12 antibody, hydroxysteroid (17-beta) dehydrogenase 12 L homeolog antibody, hydroxysteroid (17-beta) dehydrogenase 12a antibody, HSD17B12 antibody, Hsd17b12 antibody, hsd17b12.L antibody, hsd17b12a antibody

Background: Hsd17b12 catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in females. Hsd17b12 also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
Alias Symbols: 2610510O05Rik, AI172963, KIK-I, Kik1
Protein Interaction Partner: Eed, DSK2, VPS9, NUB1, UBQLN1, SQSTM1, RAD23B, PSMD4, NBR1,
Protein Size: 312

Molecular Weight: 35 kDa

Gene ID: 56348

NCBI Accession: NM_019657, NP_062631

UniProt: O70503

Pathways: Steroid Hormone Biosynthesis