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EIF4A1 antibody (Middle Region)

EIF4A1 Reactivity: Human, Rat, Mouse, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog, Saccharomyces cerevisiae, Sheep WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2783213
  • Target See all EIF4A1 Antibodies
    EIF4A1 (Eukaryotic Translation Initiation Factor 4A1 (EIF4A1))
    Binding Specificity
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 30
    • 18
    • 17
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Rat, Mouse, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog, Saccharomyces cerevisiae, Sheep
    Host
    • 27
    • 3
    Rabbit
    Clonality
    • 26
    • 4
    Polyclonal
    Conjugate
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EIF4A1 antibody is un-conjugated
    Application
    • 23
    • 9
    • 8
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    TMPSDVLEVT KKFMRDPIRI LVKKEELTLE GIRQFYINVE REEWKLDTLC
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Yeast: 92%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against EIF4A1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human EIF4A1
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    Discover our top product EIF4A1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 406 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tamarkin-Ben-Harush, Vasseur, Debart, Ulitsky, Dikstein: "Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress." in: eLife, Vol. 6, (2017) (PubMed).

  • Target
    EIF4A1 (Eukaryotic Translation Initiation Factor 4A1 (EIF4A1))
    Alternative Name
    EIF4A1 (EIF4A1 Products)
    Synonyms
    DDX2A antibody, EIF-4A antibody, EIF4A antibody, eIF-4A-I antibody, eIF4A-I antibody, BM-010 antibody, Ddx2a antibody, Eif4 antibody, ddx2a antibody, eif-4a antibody, eif4a antibody, eif4a1 antibody, fb49a04 antibody, im:7143023 antibody, wu:fb20a10 antibody, wu:fb49a04 antibody, wu:fc76a02 antibody, wu:fc96c01 antibody, wu:fd15g03 antibody, eukaryotic translation initiation factor 4A1 antibody, eukaryotic translation initiation factor 4A1 L homeolog antibody, eukaryotic initiation factor 4A-I antibody, eukaryotic translation initiation factor 4A1A antibody, EIF4A1 antibody, Eif4a1 antibody, eif4a1.L antibody, eif4a1 antibody, LOC695050 antibody, eif4a1a antibody
    Background
    EIF4A1 is an ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
    Alias Symbols: DDX2A, EIF-4A, EIF4A, eIF4A-I, eIF-4A-I
    Protein Interaction Partner: HUWE1, UBC, FUS, SUMO2, SUMO3, STAU1, MDM2, SH3RF2, TRAP1, FBXO6, ADRB2, CD81, NPM1, VCAM1, ITGA4, FN1, ESR1, LIG4, RPLP0P6, TMEM43, NDUFB11, ZBTB43, GPRC5A, EIF4G3, EIF4H, VDAC3, UQCRFS1, SDHA, RPS26, RPL19, RPL8, RPSA, ILF2, HSP90AB1, HSPA5, EIF4G2, EIF
    Protein Size: 406
    Molecular Weight
    46 kDa
    Gene ID
    1973
    NCBI Accession
    NM_001416, NP_001407
    UniProt
    P60842
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