Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) (N-Term) antibody

Details for Product No. ABIN2783214
Antigen
  • IFNLR1
  • IL28RA
  • crf2/12
  • ifnlr
  • il-28r1
  • il28ra
  • licr2
  • ifnlr1
  • CRF2-12
  • Il28ra
  • CRF2/12
  • IFNLR
  • IL-28R1
  • LICR2
  • RGD1562689
  • interferon lambda receptor 1
  • interferon, lambda receptor 1
  • interferon, lambda receptor 1 L homeolog
  • IFNLR1
  • ifnlr1
  • ifnlr1.L
  • Ifnlr1
Epitope
N-Term
15
15
8
3
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
59
20
18
3
3
2
2
1
1
1
Host
Rabbit
58
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
39
24
13
4
3
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human IL28RA
Blocking Peptide Blocking peptide for this product available: ABIN978504
Sequence EECAGTKELL CSMMCLKKQD LYNKFKGRVR TVSPSSKSPW VESEYLDYLF
Predicted Reactivity Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 77%, Rabbit: 86%, Rat: 92%
Characteristics This is a rabbit polyclonal antibody against IL28RA. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Antigen
Alternative Name IL28RA (IL28RA Antibody Abstract)
Background IL28RA belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: CRF2/12, IFNLR, IFNLR1, LICR2, il-28r1, IL-28R1, IL28RA
Protein Interaction Partner: IFNLR1, IFNL1, IFNL2, LSM8,
Protein Size: 491
Molecular Weight 54 kDa
Gene ID 163702
NCBI Accession NM_173064, NP_775087
UniProt Q5VTX8
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 491 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) (N-Term) antibody (ABIN2783214) WB Suggested Anti-IL28RA Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Po...
Western Blotting (WB) image for anti-Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) (N-Term) antibody (ABIN2783214) Host: Rabbit Target Name: IL28RA Sample Tissue: Human Fetal Lung Antibody Dilut...
Product cited in: Mucha, Majchrzak, Taciak, Hellmén, Król: "MDSCs mediate angiogenesis and predispose canine mammary tumor cells for metastasis via IL-28/IL-28RA (IFN-?) signaling." in: PLoS ONE, Vol. 9, Issue 7, pp. e103249, 2014 (PubMed).

Background publications Chae, Park, Li, Lee, Yang, Zhang, Kim, Chung: "Analysis of the variations in IL-28RA gene and their association with allergic rhinitis." in: Experimental & molecular medicine, Vol. 38, Issue 3, pp. 302-9, 2006 (PubMed).

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