IL28RA antibody (N-Term)

Catalog No. ABIN2783214

This Rabbit Polyclonal antibody specifically detects IL28RA in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Rabbit, Cow, Dog and Guinea Pig.It has been mentioned in 1 publication

Quick Overview for IL28RA antibody (N-Term) (ABIN2783214)

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL28RA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL28RA Antibody

Binding Specificity: N-Term

Sequence: EECAGTKELL CSMMCLKKQD LYNKFKGRVR TVSPSSKSPW VESEYLDYLF

Predicted Reactivity: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 77%, Rabbit: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against IL28RA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human IL28RA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 491 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IL28RA antibody (ABIN2783214)

Mucha, Majchrzak, Taciak, Hellmén, Król: "MDSCs mediate angiogenesis and predispose canine mammary tumor cells for metastasis via IL-28/IL-28RA (IFN-?) signaling." in: PLoS ONE, Vol. 9, Issue 7, pp. e103249, (2014) (PubMed).

Target Details for IL28RA

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Alternative Name: IL28RA

Background: IL28RA belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: CRF2/12, IFNLR, IFNLR1, LICR2, il-28r1, IL-28R1, IL28RA
Protein Interaction Partner: IFNLR1, IFNL1, IFNL2, LSM8,
Protein Size: 491

Molecular Weight: 54 kDa

Gene ID: 163702

NCBI Accession: NM_173064, NP_775087

UniProt: Q5VTX8