IL28RA antibody (AA 387-420)

Catalog No. ABIN6242856

Product Details anti-IL28RA Antibody

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Binding Specificity: AA 387-420

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL28RA antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IL28RA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-420 amino acids from the Central region of human IL28RA.

Clone: RB47814

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for IL28RA

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Alternative Name: IL28RA (IL28RA Products)

Synonyms: IFNLR1 antibody, IL28RA antibody, crf2/12 antibody, ifnlr antibody, il-28r1 antibody, il28ra antibody, licr2 antibody, ifnlr1 antibody, CRF2-12 antibody, Il28ra antibody, CRF2/12 antibody, IFNLR antibody, IL-28R1 antibody, LICR2 antibody, RGD1562689 antibody, interferon lambda receptor 1 antibody, interferon, lambda receptor 1 antibody, interferon, lambda receptor 1 L homeolog antibody, IFNLR1 antibody, ifnlr1 antibody, ifnlr1.L antibody, Ifnlr1 antibody

Background: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Molecular Weight: 57653

UniProt: Q8IU57