APEH antibody (Middle Region)

Catalog No. ABIN2783265

The Rabbit Polyclonal anti-APEH antibody (ABIN2783265) specifically detects APEH in WB. The antibody is reactive with Human, Mouse, Rat, Guinea Pig, Cow, Horse, Rabbit, Zebrafish (Danio rerio) and Dog samples.

Quick Overview for APEH antibody (Middle Region) (ABIN2783265)

Target: APEH (N-Acylaminoacyl-Peptide Hydrolase (APEH))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APEH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-APEH Antibody

Binding Specificity: Middle Region

Sequence: GSTGFGQDSI LSLPGNVGHQ DVKDVQFAVE QVLQEEHFDA SHVALMGGSH

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against APEH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APEH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 732 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APEH

Target: APEH (N-Acylaminoacyl-Peptide Hydrolase (APEH))

Alternative Name: APEH

Background: APEH is the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.
Alias Symbols: ACPH, APH, D3F15S2, D3S48E, DNF15S2, MGC2178, OPH, AARE
Protein Interaction Partner: IST1, UBC, LGALS8, APEH, SNX6, CAND1, TOLLIP, CYHR1, JMJD6, HSPA4L, IPO7, DNM1L, VPS26A, NMI, H1FX, ZYX, TBCD, TARS, STAT1, SHMT2, SHMT1, PPM1G, SERPINE2, PAWR, LAMP2, KARS, HIST1H1C, GARS, CTTN, CARS, PREPL, SHBG, UBA5, TMEM62,
Protein Size: 732

Molecular Weight: 81 kDa

Gene ID: 327

NCBI Accession: NM_001640, NP_001631

UniProt: P13798