CDY1 antibody (C-Term)

Catalog No. ABIN2783449

There is 1 publication for this product available. The Rabbit Polyclonal anti-CDY1 antibody is suitable to detect CDY1 in samples from Human, Rat, Mouse, Cow, Dog, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for CDY1 antibody (C-Term) (ABIN2783449)

Target: CDY1 (Chromodomain Protein, Y-Linked, 1 (CDY1))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDY1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDY1 Antibody

Binding Specificity: C-Term

Purpose: CDY1 Antibody - C-terminal region

Sequence: FPRTWWQSAE DVHREKIQLD LEAEFYFTHL IVMFKSPRPA AMVLDRSQDF

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 85%, Human: 100%, Mouse: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CDY1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDY1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8097027

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CDY1 antibody (ABIN2783449)

Stouffs, Tournaye, Van der Elst, Haentjens, Liebaers, Lissens: "Do we need to search for gr/gr deletions in infertile men in a clinical setting?" in: Human reproduction (Oxford, England), Vol. 23, Issue 5, pp. 1193-9, (2008) (PubMed).

Target Details for CDY1

Target: CDY1 (Chromodomain Protein, Y-Linked, 1 (CDY1))

Alternative Name: CDY1

Background:

Background Information: CDY1 containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein.This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region, this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.

Gene Name: Chromodomain protein, Y-linked, 1

Alternative Symbols: CDY, CDY1A

Protein Name: cDNA FLJ76680, highly similar to Homo sapiens chromodomain protein, Y-linked, 1 (CDY1), transcript variant 2, mRNA EMBL BAF85007.1

Molecular Weight: 62kDa

Gene ID: 9085

NCBI Accession: NP_004671

UniProt: A8K8F3