QPCT antibody (Middle Region)
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- Target See all QPCT Antibodies
- QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Cow, Dog, Horse, Sheep, Guinea Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This QPCT antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA
- Predicted Reactivity
- Cow: 86%, Dog: 79%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 100%, Sheep: 86%
- Characteristics
- This is a rabbit polyclonal antibody against QPCT. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human QPCT
- Top Product
- Discover our top product QPCT Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 361 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))
- Alternative Name
- QPCT (QPCT Products)
- Synonyms
- GCT antibody, QC antibody, sQC antibody, QPCT antibody, 5730422A13Rik antibody, Qpctl1 antibody, RGD1562284 antibody, qpct antibody, glutaminyl-peptide cyclotransferase antibody, glutaminyl-peptide cyclotransferase (glutaminyl cyclase) antibody, glutaminyl-peptide cyclotransferase L homeolog antibody, QPCT antibody, Qpct antibody, M6_Spy0443 antibody, M5005_Spy_0416 antibody, M28_Spy0404 antibody, CJA_2408 antibody, CCNA_02733 antibody, Tsp_03182 antibody, qpct.L antibody
- Background
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QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GCT, QC, sQC
Protein Interaction Partner: CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, NEDD8, UBC,
Protein Size: 361 - Molecular Weight
- 38 kDa
- Gene ID
- 25797
- NCBI Accession
- NM_012413, NP_036545
- UniProt
- Q16769
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