PGS1 antibody (C-Term)

Catalog No. ABIN2783550

There are 2+ publications for this product available. The Rabbit Polyclonal anti-PGS1 antibody is suitable to detect PGS1 in samples from Human, Rat, Mouse, Cow, Guinea Pig, Dog, Horse, Rabbit and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for PGS1 antibody (C-Term) (ABIN2783550)

Target: PGS1 (Phosphatidylglycerophosphate Synthase 1 (PGS1))

Reactivity: Human, Rat, Mouse, Cow, Guinea Pig, Dog, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PGS1 Antibody

Binding Specificity: C-Term

Purpose: PGS1 Antibody - C-terminal region

Sequence: RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC LTLIGSPNFG YRSVHRDLEA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PGS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PGS1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8108001

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PGS1 antibody (ABIN2783550)

Croston, Shepherd, Thapa, Nichols, Lewis, Dabkowski, Jagannathan, Baseler, Hollander: "Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart." in: Life sciences, Vol. 93, Issue 8, pp. 313-22, (2013) (PubMed).

Kiebish, Yang, Sims, Jenkins, Liu, Mancuso, Zhao, Guan, Abendschein, Han, Gross: "Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25086-97, (2012) (PubMed).

Target Details for PGS1

Target: PGS1 (Phosphatidylglycerophosphate Synthase 1 (PGS1))

Alternative Name: PGS1

Background:

Background Information: PGS1 functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.

Gene Name: Phosphatidylglycerophosphate synthase 1

Alternative Symbols: DKFZP762M186, MGC131960

Protein Name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Molecular Weight: 60kDa

Gene ID: 9489

UniProt: Q32NB8