SETDB2 antibody (N-Term)

Catalog No. ABIN2783580

The Rabbit Polyclonal anti-SETDB2 antibody (ABIN2783580) specifically detects SETDB2 in WB. The antibody is reactive with Human, Rat and Guinea Pig samples.

Quick Overview for SETDB2 antibody (N-Term) (ABIN2783580)

Target: SETDB2 (SET Domain, Bifurcated 2 (SETDB2))

Reactivity: Human, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETDB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SETDB2 Antibody

Binding Specificity: N-Term

Purpose: SETDB2 Antibody - N-terminal region

Sequence: ASQKEVNAQS SDPMPVTQKE QENKSNAFPS TSCENSFPED CTFLTTGNKE

Predicted Reactivity: Guinea Pig: 92%, Human: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against SETDB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SETDB2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48955-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SETDB2

Target: SETDB2 (SET Domain, Bifurcated 2 (SETDB2))

Alternative Name: SETDB2

Background:

Background Information: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity.

Gene Name: SET domain, bifurcated 2

Alternative Symbols: CLLD8, CLLL8, KMT1F, C13orf4

Protein Name: Histone-lysine N-methyltransferase SETDB2

Molecular Weight: 77kDa

Gene ID: 83852

UniProt: Q96T68