FCRLA antibody (C-Term)

Catalog No. ABIN2784054

The Rabbit Polyclonal anti-FCRLA antibody is suitable to detect FCRLA in samples from Human. It has been validated for WB.

Quick Overview for FCRLA antibody (C-Term) (ABIN2784054)

Target: FCRLA (Fc Receptor-Like A (FCRLA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FCRLA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FCRLA Antibody

Binding Specificity: C-Term

Purpose: FCRLA Antibody - C-terminal region

Sequence: MPDPHLYHQM GLLLKHMQDV RVLLGHLLME LRELSGHRKP GTTKATAE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against FCRLA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FCRLA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50111-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FCRLA

Target: FCRLA (Fc Receptor-Like A (FCRLA))

Alternative Name: FCRLA

Background:

Background Information: Receptors for the Fc fragment of IgG, or FCGRs, are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. FCRLA may be implicated in B-cell differentiation and lymphomagenesis.Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-742 BM471887.1 3-744 743-1338 BC006521.2 558-1153 1339-1684 BX112608.1 318-663 1685-2357 BX649184.1 2243-2915

Gene Name: Fc receptor-like A

Alternative Symbols: FCRL, FCRX, FREB, FCRL1, FCRLX, FCRLb, FCRLd, FCRLe, FCRLM1, FCRLc1, FCRLc2

Protein Name: Fc receptor-like A

Molecular Weight: 41kDa

Gene ID: 84824

NCBI Accession: NP_116127

UniProt: Q7L513