PYHIN1 antibody (N-Term)

Catalog No. ABIN2784367

The Rabbit Polyclonal anti-PYHIN1 antibody has been validated for WB. It is suitable to detect PYHIN1 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit.

Quick Overview for PYHIN1 antibody (N-Term) (ABIN2784367)

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYHIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PYHIN1 Antibody

Binding Specificity: N-Term

Sequence: ANNYKKIVLL KGLEVINDYH FRIVKSLLSN DLKLNPKMKE EYDKIQIADL

Predicted Reactivity: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 93%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against PYHIN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 492 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PYHIN1

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Alternative Name: PYHIN1

Background: PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Alias Symbols: IFIX, MGC23885, RP11-520H16.1
Protein Interaction Partner: MDM2,
Protein Size: 492

Molecular Weight: 55 kDa

Gene ID: 149628

NCBI Accession: NM_152501, NP_689714

UniProt: Q6K0P9