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PYHIN1 antibody (Pyrin and HIN Domain Family, Member 1) (N-Term) Primary Antibody

PYHIN1 Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784367
$389.00
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100 μL
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  • Target
    PYHIN1
    Binding Specificity
    • 10
    • 9
    • 7
    • 4
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    This PYHIN1 antibody is un-conjugated
    Application
    • 20
    • 18
    • 15
    • 15
    • 2
    Western Blotting (WB)
    Sequence
    ANNYKKIVLL KGLEVINDYH FRIVKSLLSN DLKLNPKMKE EYDKIQIADL
    Predicted Reactivity
    Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 93%, Rat: 85%
    Characteristics
    This is a rabbit polyclonal antibody against PYHIN1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 492 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PYHIN1
    Alternative Name
    PYHIN1 (PYHIN1 Antibody Abstract)
    Synonyms
    IFIX, RP11-520H16.1, 4930422C14, AI447904, Ifi209, Ifix, pyrin and HIN domain family member 1, interferon activated gene 209, PYHIN1, Ifi209
    Background
    PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
    Alias Symbols: IFIX, MGC23885, RP11-520H16.1
    Protein Interaction Partner: MDM2,
    Protein Size: 492
    Molecular Weight
    55 kDa
    Gene ID
    149628
    NCBI Accession
    NM_152501, NP_689714
    UniProt
    Q6K0P9
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