MDFIC antibody (Middle Region)

Catalog No. ABIN2784370

Product Details anti-MDFIC Antibody

Target: MDFIC (MyoD Family Inhibitor Domain Containing (MDFIC))

Binding Specificity: Middle Region

Reactivity: Human, Rabbit, Cow, Pig, Dog, Horse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDFIC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PQLQTSAQVP SGEEIGKIKN GHTGLSNGNG IHHGAKHGSA DNRKLSAPVS

Predicted Reactivity: Cow: 79%, Dog: 86%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against MDFIC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MDFIC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 355 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MDFIC

Target: MDFIC (MyoD Family Inhibitor Domain Containing (MDFIC))

Alternative Name: MDFIC (MDFIC Products)

Synonyms: HIC antibody, Kdt1 antibody, Mdfid antibody, MyoD family inhibitor domain containing antibody, MyoD family inhibitor domain containing S homeolog antibody, MDFIC antibody, Mdfic antibody, mdfic.S antibody

Background: MDFIC is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization, p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain.This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization, p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain.
Alias Symbols: HIC
Protein Interaction Partner: SOCS4, tat, RPS6KA5, CSNK2A1, MDFIC, CDK9, CCNT1,
Protein Size: 355

Molecular Weight: 37 kDa

Gene ID: 29969

NCBI Accession: NM_199072, NP_951038

UniProt: Q9P1T7