CD42b antibody (Middle Region)

Catalog No. ABIN2784513

Product Details anti-CD42b Antibody

Target: CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD42b antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TPTPKLEKLS LANNNLTELP AGLLNGLENL DTLLLQENSL YTIPKGFFGS

Predicted Reactivity: Guinea Pig: 86%, Human: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against GP1BA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GP1BA

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD42b

Target: CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))

Alternative Name: GP1BA (GP1BA Products)

Synonyms: BDPLT1 antibody, BDPLT3 antibody, BSS antibody, CD42B antibody, CD42b-alpha antibody, DBPLT3 antibody, GP1B antibody, GPIbA antibody, VWDP antibody, GP1BA antibody, GPIba antibody, GPIbalpha antibody, glycoprotein Ib platelet alpha subunit antibody, glycoprotein Ib (platelet), alpha polypeptide antibody, glycoprotein 1b, alpha polypeptide antibody, GP1BA antibody, Gp1ba antibody

Background: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.
Alias Symbols: BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3, GPIbalpha, CD42b-alpha
Protein Size: 346

Molecular Weight: 38 kDa

Gene ID: 2811

NCBI Accession: NM_000173, NP_000164

UniProt: P07359