HAX1 antibody (Middle Region)

Catalog No. ABIN2784795

This anti-HAX1 antibody is a Rabbit Polyclonal antibody detecting HAX1 in WB and IHC. Suitable for Human, Mouse, Rat, Guinea Pig, Horse, Cow and Dog.

Quick Overview for HAX1 antibody (Middle Region) (ABIN2784795)

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HAX1 Antibody

Binding Specificity: Middle Region

Sequence: LPGPESETPG ERLREGQTLR DSMLKYPDSH QPRIFGGVLE SDARSESPQP

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HAX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HAX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 279 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HAX1

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Alternative Name: HAX1

Background: HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HCLSBP1, HS1BP1, SCN3
Protein Interaction Partner: ERLIN2, UBC, BIRC3, CEP250, TUBGCP2, TUBGCP3, MAPK10, HIPK1, DYRK4, ZNF420, POLR1D, ZNRD1, RBX1, STAT5B, RPA1, PPP3CC, CFTR, EWSR1, SHC1, HTRA2, NEDD4L, CUL3, CUL4A, PIDD1, SVIL, EBNA-LP, AMFR, HNF4G, AKAP10, TUBB4A, ABCC4, MATN4, EIF3D, RGS1, HSP90AB1, H
Protein Size: 279

Molecular Weight: 31 kDa

Gene ID: 10456

NCBI Accession: NM_006118, NP_006109

UniProt: O00165

Pathways: Regulation of Actin Filament Polymerization