HAX1 antibody (AA 1-279)

Catalog No. ABIN5775949

The Mouse Monoclonal anti-HAX1 antibody is suitable to detect HAX1 in samples from Human. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for HAX1 antibody (AA 1-279) (ABIN5775949)

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HAX1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT3C5

Product Details anti-HAX1 Antibody

Binding Specificity: AA 1-279

Purpose: Human HAX-1 antibody

Purification: Purified

Immunogen: Recombinant human HAX1 (1-279aa) purified from E. coli

Isotype: IgG2b kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for HAX1

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Alternative Name: HAX-1

Background: HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.

NCBI Accession: NP_006109

Pathways: Regulation of Actin Filament Polymerization