KATNA1 antibody (C-Term)

Catalog No. ABIN2784857

This Rabbit Polyclonal antibody specifically detects KATNA1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for KATNA1 antibody (C-Term) (ABIN2784857)

Target: KATNA1 (Katanin P60 (ATPase Containing) Subunit A 1 (KATNA1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KATNA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KATNA1 Antibody

Binding Specificity: C-Term

Purpose: Katna1 Antibody - C-terminal region

Sequence: DDPSKMVMVL AATNFPWDID EALRRRLEKR IYIPLPSAKG REELLRISLR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against Katna1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52277-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KATNA1

Target: KATNA1 (Katanin P60 (ATPase Containing) Subunit A 1 (KATNA1))

Alternative Name: Katna1

Background:

Targeted Subunit: A1

Background Information: Katna1 severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as that seen during disassembly of interphase microtubules at the G2-M transition.It may also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body allows their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth.

Gene Name: Katanin p60 (ATPase-containing) subunit A1

Alternative Symbols: -

Protein Name: Katanin p60 ATPase-containing subunit A1

Molecular Weight: 54kDa

Gene ID: 23924

NCBI Accession: NP_035965

UniProt: Q9WV86

Pathways: Microtubule Dynamics