ACVR1C/ALK7 antibody (N-Term)

Catalog No. ABIN2785115

The Rabbit Polyclonal anti-ACVR1C/ALK7 antibody (ABIN2785115) specifically detects ACVR1C/ALK7 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Horse and Rabbit samples.

Quick Overview for ACVR1C/ALK7 antibody (N-Term) (ABIN2785115)

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR1C/ALK7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACVR1C/ALK7 Antibody

Binding Specificity: N-Term

Sequence: QVFCHSSNNV TKTECCFTDF CNNITLHLPT ASPNAPKLGP MELAIIITVP

Predicted Reactivity: Cow: 100%, Dog: 83%, Guinea Pig: 80%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 81%, Rabbit: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against ACVR1C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1C

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 493 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACVR1C/ALK7

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Alternative Name: ACVR1C

Background: ACVR1C is a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM].
Alias Symbols: ACVRLK7, ALK7
Protein Interaction Partner: HSP90AA1, TDGF1, INHBB,
Protein Size: 493

Molecular Weight: 55 kDa

Gene ID: 130399

NCBI Accession: NM_145259, NP_660302

UniProt: Q8NER5

Pathways: Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity