SOCS7 antibody (N-Term)

Catalog No. ABIN2785525

The Rabbit Polyclonal anti-SOCS7 antibody is suitable to detect SOCS7 in samples from Human, Mouse, Rat, Cow, Rabbit, Pig, Horse, Dog and Guinea Pig. It has been validated for WB.

Quick Overview for SOCS7 antibody (N-Term) (ABIN2785525)

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Pig, Horse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SOCS7 Antibody

Binding Specificity: N-Term

Purpose: SOCS7 Antibody - N-terminal region

Sequence: GSAGRELDAG RKPKLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SOCS7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP53701-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7

Background:

Background Information: SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. It functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. It inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Name: suppressor of cytokine signaling 7

Alternative Symbols: NAP4, NCKAP4

Protein Name: Suppressor of cytokine signaling 7

Molecular Weight: 36kDa

Gene ID: 30837

UniProt: O14512