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SOCS7 antibody (N-Term)
SOCS7
Reactivity: Human, Mouse, Rat, Rabbit, Cow, Pig, Horse, Dog, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SOCS7 Antibody
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Target
See all SOCS7 Antibodies
SOCS7
(Suppressor of Cytokine Signaling 7 (SOCS7))
Binding Specificity
All epitopes for SOCS7 antibodies
N-Term
Reactivity
Human, Mouse, Rat, Rabbit, Cow, Pig, Horse, Dog, Guinea Pig
Host
All hosts for SOCS7 antibodies
Rabbit
Clonality
All clonalities for SOCS7 antibodies
Polyclonal
Conjugate
All conjugates for SOCS7 antibodies
This SOCS7 antibody is un-conjugated
Application
All applications for SOCS7 antibodies
Western Blotting (WB)
Sequence
GSAGRELDAG RKPKLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS
Predicted Reactivity
Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 100%, Rat: 92%
Characteristics
This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human SOCS7
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for SOCS7
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Target
SOCS7
(Suppressor of Cytokine Signaling 7 (SOCS7))
Alternative Name
SOCS7 (SOCS7 Products )
Synonyms
NAP4 antibody, NCKAP4 antibody, SOCS4 antibody, SOCS6 antibody, 2310063P06Rik antibody, C85125 antibody, Nap4 antibody, GB13951 antibody, zgc:175115 antibody, SOCS7 antibody, socs7 antibody, suppressor of cytokine signaling 7 antibody, suppressor of cytokine signaling antibody, SOCS7 antibody, Socs7 antibody, LOC413772 antibody, socs7 antibody
Background
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. It functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. It inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2, Protein Size: 331
Molecular Weight
36 kDa
Gene ID
30837
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