Fgr antibody (Middle Region)

Catalog No. ABIN2785753

This Rabbit Polyclonal antibody specifically detects Fgr in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for Fgr antibody (Middle Region) (ABIN2785753)

Target: Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fgr antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Fgr Antibody

Binding Specificity: Middle Region

Sequence: CPPGCPASLY EAMEQTWRLD PEERPTFEYL QSFLEDYFTS AEPQYQPGDQ

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against FGR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FGR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 529 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Fgr

Target: Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))

Alternative Name: FGR

Background: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alias Symbols: FLJ43153, MGC75096, SRC2, c-fgr, c-src2, p55c-fgr, p58c-fgr, p55-Fgr, p58-Fgr
Protein Interaction Partner: IKBKG, STAT3, HSP90AA1, ERBB2, NR1I2, UBC, DOK1, KHDRBS1, SYK, SH3KBP1, FASLG, INPP5D, SLAMF1, VDR, HCLS1, CCR3, DAB2, PTK2, CD24, WAS, SRC, CBL, FGR, SNCA, YWHAQ, CSK, ARRB1, NCOA6,
Protein Size: 529

Molecular Weight: 59 kDa

Gene ID: 2268

NCBI Accession: NM_001042729, NP_001036194

UniProt: P09769

Pathways: Sensory Perception of Sound, Stem Cell Maintenance, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling