Pellino 3 antibody (N-Term)

Catalog No. ABIN2785761

The Rabbit Polyclonal anti-Pellino 3 antibody is suitable to detect Pellino 3 in samples from Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Guinea Pig and Dog. It has been validated for WB.

Quick Overview for Pellino 3 antibody (N-Term) (ABIN2785761)

Target: Pellino 3 (PELI3) (Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3))

Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Guinea Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Pellino 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Pellino 3 Antibody

Binding Specificity: N-Term

Purpose: PELI3 Antibody - N-terminal region

Sequence: VLEGNPEVGS PRTSDLQHRG NKGSCVLSSP GEDAQPGEEP IKYGELIVLG

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 100%, Rabbit: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against PELI3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PELI3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8107763

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Pellino 3

Target: Pellino 3 (PELI3) (Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3))

Alternative Name: PELI3

Background:

Background Information: Toll-like receptors (TLRs) and IL1R (IL1R1) are part of the innate immune response aimed at mobilizing defense mechanisms in response in infection or injury. Pellino proteins, such as PELI3, are intermediate components in the signaling cascades initiated by TLRs and IL1R.Toll-like receptors (TLRs, see MIM 603030) and IL1R (IL1R1, MIM 147810) are part of the innate immune response aimed at mobilizing defense mechanisms in response in infection or injury. Pellino proteins, such as PELI3, are intermediate components in the signaling cascades initiated by TLRs and IL1R (Jensen and Whitehead, 2003 [PubMed 12874243]).[supplied by OMIM].

Gene Name: Pellino E3 ubiquitin protein ligase family member 3

Alternative Symbols: MGC35521

Protein Name: E3 ubiquitin-protein ligase pellino homolog 3

Molecular Weight: 48kDa

Gene ID: 246330

NCBI Accession: NP_001091980

UniProt: Q8N2H9

Pathways: Toll-Like Receptors Cascades