FCN1 antibody (Middle Region)

Catalog No. ABIN2785793

Product Details anti-FCN1 Antibody

Target: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Pig, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FCN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GSQLGEFWLG NDNIHALTAQ GSSELRVDLV DFEGNHQFAK YKSFKVADEA

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 79%, Horse: 82%, Human: 100%, Mouse: 77%, Pig: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against FCN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FCN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 326 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FCN1

Target: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Alternative Name: FCN1 (FCN1 Products)

Synonyms: FCNM antibody, FCNB antibody, FCN2 antibody, FCN1 antibody, ficolin 1 antibody, ficolin (collagen/fibrinogen domain containing) 1 antibody, ficolin-1 antibody, FCN1 antibody, Fcn1 antibody, LOC100069029 antibody

Background: The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1(FCN1) is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FCNM
Protein Interaction Partner: FCN1, TGFB1, ELN,
Protein Size: 326

Molecular Weight: 32 kDa

Gene ID: 2219

NCBI Accession: NM_002003, NP_001994

UniProt: O00602

Pathways: Complement System