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KPNA1 antibody (N-Term)

KPNA1 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785822
  • Target See all KPNA1 Antibodies
    KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
    Binding Specificity
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 36
    • 17
    • 16
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
    Host
    • 26
    • 8
    • 1
    • 1
    Rabbit
    Clonality
    • 30
    • 6
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KPNA1 antibody is un-conjugated
    Application
    • 25
    • 14
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    TTPGKENFRL KSYKNKSLNP DEMRRRREEE GLQLRKQKRE EQLFKRRNVA
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against KPNA1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA1
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    Discover our top product KPNA1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 538 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Theodore, Kawai, Yang, Kleshchenko, Reddy, Villalta, Arinze: "Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2." in: The Journal of biological chemistry, Vol. 283, Issue 14, pp. 8984-94, (2008) (PubMed).

  • Target
    KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
    Alternative Name
    KPNA1 (KPNA1 Products)
    Synonyms
    IPOA5 antibody, NPI-1 antibody, RCH2 antibody, SRP1 antibody, AW494490 antibody, NPI1 antibody, Rch2 antibody, mSRP1 antibody, si:ch211-161h7.7 antibody, karyopherin subunit alpha 1 antibody, importin alpha-1 subunit antibody, karyopherin (importin) alpha 1 antibody, karyopherin alpha 1 (importin alpha 5) antibody, KPNA1 antibody, Kpna1 antibody, EHI_124900 antibody, kpna1 antibody
    Background
    Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. KPNA1 interacts with RAG1 and may play a role in V(D)J recombination.Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: IPOA5, NPI-1, RCH2, SRP1
    Protein Interaction Partner: UBC, TAF9, CLK4, NUP50, ANP32B, XRN2, rev, TRMT61A, KCTD12, NPM1, GABPA, DCAF6, LIMCH1, HECW2, CLK3, HDAC2, HDAC1, GOPC, HDAC6, CRADD, LMO4, BCAR3, FOSL1, SKP2, ORC4, IL1RAP, AICDA, TP53BP1, KPNB1, RAG1, NOSIP, DCAF8, ANP32A, CAND1, COPS5, CUL1, CUL3, CUL
    Protein Size: 538
    Molecular Weight
    60 kDa
    Gene ID
    3836
    NCBI Accession
    NM_002264, NP_002255
    UniProt
    P52294
    Pathways
    M Phase, Protein targeting to Nucleus
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