LOXL1 antibody (Middle Region)

Catalog No. ABIN2785879

This Rabbit Polyclonal antibody specifically detects LOXL1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Pig and Zebrafish (Danio rerio).

Quick Overview for LOXL1 antibody (Middle Region) (ABIN2785879)

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LOXL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LOXL1 Antibody

Binding Specificity: Middle Region

Purpose: LOXL1 Antibody - middle region

Sequence: YRPNQNGRGL PDLVPDPNYV QASTYVQRAH LYSLRCAAEE KCLASTAYAP

Predicted Reactivity: Cow: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against LOXL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LOXL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54781-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LOXL1

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Alternative Name: LOXL1

Background:

Background Information: LOXL1 is a member of the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Lysyl oxidase-like 1

Alternative Symbols: LOL, LOXL

Protein Name: Lysyl oxidase homolog 1

Molecular Weight: 53kDa

Gene ID: 4016

NCBI Accession: NP_005567

UniProt: Q08397