COG4 antibody (Middle Region)

Catalog No. ABIN2786106

This Rabbit Polyclonal antibody specifically detects COG4 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).It has been mentioned in 1 publication

Quick Overview for COG4 antibody (Middle Region) (ABIN2786106)

Target: COG4 (Component of Oligomeric Golgi Complex 4 (COG4))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COG4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COG4 Antibody

Binding Specificity: Middle Region

Purpose: COG4 Antibody - middle region

Sequence: TSLVAVELEK VVLKSTFNRL GGLQFDKELR SLIAYLTTVT TWTIRDKFAR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against COG4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COG4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55243-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-COG4 antibody (ABIN2786106)

Suzuki, Fujisawa, Ando, Niino, Ohsawa, Shimokata, Ohta: "Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae." in: Neurology, Vol. 63, Issue 9, pp. 1711-3, (2004) (PubMed).

Target Details for COG4

Target: COG4 (Component of Oligomeric Golgi Complex 4 (COG4))

Alternative Name: COG4

Background:

Targeted Subunit: 4

Background Information: Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4.Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002 [PubMed 11980916]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-265 AK096557.1 1-265 266-555 BP282697.1 230-519 556-1072 AU125729.1 34-550 1073-2838 AL050101.1 375-2140

Gene Name: Component of oligomeric golgi complex 4

Alternative Symbols: COD1, CDG2J, SWILS

Protein Name: Conserved oligomeric Golgi complex subunit 4

Molecular Weight: 89kDa

Gene ID: 25839

NCBI Accession: NP_056201

UniProt: Q9H9E3