FANCE antibody (Middle Region)

Catalog No. ABIN2786176

The Rabbit Polyclonal anti-FANCE antibody (ABIN2786176) specifically detects FANCE in WB. The antibody is reactive with Human, Cow, Horse, Pig, Rabbit and Dog samples.

Quick Overview for FANCE antibody (Middle Region) (ABIN2786176)

Target: FANCE (Fanconi Anemia, Complementation Group E (FANCE))

Reactivity: Human, Cow, Horse, Pig, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCE antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FANCE Antibody

Binding Specificity: Middle Region

Purpose: FANCE Antibody - middle region

Sequence: SPQAPDPEEE ENRDSQQPGK RRKDSEEEAA SPEGKRVPKR LRCWEEEEDH

Predicted Reactivity: Cow: 86%, Dog: 79%, Horse: 85%, Human: 100%, Pig: 79%, Rabbit: 79%

Characteristics: This is a rabbit polyclonal antibody against FANCE. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FANCE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55381-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FANCE

Target: FANCE (Fanconi Anemia, Complementation Group E (FANCE))

Alternative Name: FANCE

Background:

Background Information: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex.The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Fanconi anemia, complementation group E

Alternative Symbols: FAE, FACE

Protein Name: Fanconi anemia group E protein

Molecular Weight: 59kDa

Gene ID: 2178

NCBI Accession: NP_068741

UniProt: Q9HB96

Pathways: DNA Damage Repair