FYN antibody (Middle Region)

Catalog No. ABIN2786269

The Rabbit Polyclonal anti-FYN antibody is suitable to detect FYN in samples from Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for FYN antibody (Middle Region) (ABIN2786269)

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FYN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FYN Antibody

Binding Specificity: Middle Region

Sequence: CPQDCPISLH ELMIHCWKKD PEERPTFEYL QSFLEDYFTA TEPQYQPGEN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against FYN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FYN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 537 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FYN

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Alternative Name: FYN

Background: FYN is a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein.
Alias Symbols: MGC45350, SLK, SYN, p59-FYN
Protein Interaction Partner: IFITM3, EFS, WBP11, MAPT, IKBKG, PRMT6, KDM1A, SUV39H1, CMA1, TNF, IL1B, STAT3, HSP90AA1, GRIN2B, GRIN1, Mbp, MED28, CBL, TCAP, UBC, PDE4D, ENO1, SNCA, FYB, CLTC, LAT, SKAP2, ADAM15, nef, CD244, FYN, CAV1, VAV2, VAV1, ATXN1, PTPN11, KCNJ3, KCNA5, KCNA4, K
Protein Size: 537

Molecular Weight: 59 kDa

Gene ID: 2534

NCBI Accession: NM_002037, NP_002028

UniProt: P06241

Pathways: JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling