ERCC1 antibody (N-Term)

Catalog No. ABIN2786445

This Rabbit Polyclonal antibody specifically detects ERCC1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig and Rabbit.

Quick Overview for ERCC1 antibody (N-Term) (ABIN2786445)

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ERCC1 Antibody

Binding Specificity: N-Term

Sequence: TVDTSAQAAP QTYAEYAISQ PLEGAGATCP TGSEPLAGET PNQALKPGAK

Predicted Reactivity: Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against ERCC1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human ERCC1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ERCC1

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Alternative Name: ERCC1

Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Alias Symbols: UV20, COFS4, RAD10
Protein Size: 213

Molecular Weight: 23 kDa

Gene ID: 2067

NCBI Accession: NM_001166049, NP_001159521

UniProt: P07992

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response