PPOX antibody (C-Term)

Catalog No. ABIN2786510

The Rabbit Polyclonal anti-PPOX antibody is suitable to detect PPOX in samples from Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse and Dog. It has been validated for WB.

Quick Overview for PPOX antibody (C-Term) (ABIN2786510)

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPOX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PPOX Antibody

Binding Specificity: C-Term

Purpose: PPOX Antibody - C-terminal region

Sequence: GGALHALPTG LRGLLRPSPP FSKPLFWAGL RELTKPRGKE PDETVHSFAQ

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PPOX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human PPOX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56096-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPOX

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Alternative Name: PPOX

Background:

Background Information: This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene Name: protoporphyrinogen oxidase

Alternative Symbols: VP, PPO, V290M

Protein Name: protoporphyrinogen oxidase

Molecular Weight: 17kDa

Gene ID: 5498

NCBI Accession: NP_000300

UniProt: P50336

Pathways: Synaptic Membrane, Feeding Behaviour