PEX5 antibody (N-Term)

Catalog No. ABIN503842

This Rabbit Polyclonal antibody specifically detects PEX5 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig and Cow.

Quick Overview for PEX5 antibody (N-Term) (ABIN503842)

Target: PEX5 (Peroxisomal Biogenesis Factor 5 (PEX5))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEX5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PEX5 Antibody

Binding Specificity: N-Term

Sequence: TATDRWYDEY HPEEDLQHTA SDFVAKVDDP KLANSEFLKF VRQIGEGQVS

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PEX5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PEX5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 631 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PEX5

Target: PEX5 (Peroxisomal Biogenesis Factor 5 (PEX5))

Alternative Name: PEX5

Background: PEX5 binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD).
Alias Symbols: PTS1R, PXR1, PTS1-BP
Protein Interaction Partner: CAPRIN2, CCDC14, TOMM7, PRR13, GDPD5, ZNF772, EP400NL, TM6SF1, ACOT8, RPL14, MKRN3, S100A6, LDHB, RANBP6, GSTK1, ZADH2, TYSND1, HSDL2, ACAD11, LONP2, PECR, HSD17B4, HOXA7, EHHADH, ECH1, CRAT, CAT, BRCA1, ACOX1, DECR2, HACL1, DHRS4, ECI2, AGPS, GNPAT, UBC,
Protein Size: 631

Molecular Weight: 70 kDa

Gene ID: 5830

NCBI Accession: NM_000319, NP_000310

Pathways: Monocarboxylic Acid Catabolic Process